Research Assistant Professor - Fixed
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Job no: 479848
Work type: Faculty/Academic Staff
Major Administrative Unit / College:
College Of Human Medicine
Translation Science & Molecular Med 40000320
Salary Commensurate with Experience
Location: Grand Rapids
Categories: Full Time (90-100%), Fixed Term Faculty, Research/Scientific
This Research Assistant Professor (RAP) position will coordinate several lines of research in the Manfredsson laboratory. Specifically, the RAP will be responsible for overseeing research projects investigating the mechanisms of alpha-synuclein toxicity and the functional role of this protein in both the central and peripheral nervous systems. In this role, it is expected that the RAP will manage several trainees and technicians. In addition, the RAP will be involved in viral vector (AAV) production, genome and capsid design, and additional research involving the basic biology of recombinant viral vectors. Moreover, the RAP will be responsible for generating grant applications aimed at sustaining the research program as well as to facilitate the transition of the RAP in to an independent research position. In addition, the RAP is expected to write up results for publication in a timely manner.
The RAP will take a primary role in overseeing and developing a research program involving the manufacture of viral vectors, recombinant proteins and evaluating models of alpha-synuclein pathology in order to study the role of α-syn in normal neuronal function and disease. In addition, the RAP will participate in the day to day operations of the research lab; duties will include collaborative experimental design, conducting experimental laboratory work, analyzing and writing up results for publication in peer-reviewed journals. This position is located at 333 Bostwick Ave NE, Grand Rapids, MI.
Early career scientist with a doctoral degree in natural sciences and at least three years of postdoctoral experience in a basic science laboratory. Skills required include:
- A strong background (with the corresponding publication record) in the biology and pathobiology of the protein alpha-synuclein,
- Experience with recombinant protein production, cell culture, AAV viral vector production,
- Evaluation of miRNA/shRNA/CRISPR products and data generation and handling,
- Data interpretation,
- Writing up laboratory procedures and results,
- Supervision of students and software usage.
- Experience with cloning and protein, analysis, examination of protein-protein interactions, immunoprecipitation, cell culture development and maintenance, and microscopy are considered strengths.
- Good command of written and spoken English is required.
Advanced techniques such as small animal handling, immunohistochemistry, knowledge of brain anatomy, tissue sectioning, fluorescence microscopy animal handling, survival surgery, and behavioral testing.
Required Application Materials
CV, Coverletter, Contact information for references
Review of applications will begin on December 26, 2017 and continue until the position is filled.
Summary of Health Risks
Work with animals or unfixed animal tissue
Advertised: Eastern Standard Time
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